Creo Topology Optimization > Optimization Setup > About Setting Up the Optimization
  
About Setting Up the Optimization
When you set up the optimization, you create items to include in the optimization study by performing the action below:
Create an analysis to contain the desired loads, constraints, and boundary conditions. You select from those created when the model was set up.
Define topology regions to optimize, including fabrication constraints.
Select regions to exclude from the optimization.
Select design objectives to minimize or maximize physical features.
Select design constraints.